学习资源
科普文章
构型Format的重要性:几何结构定义了双特异性抗体的功能(二) [1]
参考文献:
1.Dickopf, S., G.J. Georges, and U. Brinkmann, Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies. Computational and Structural Biotechnology Journal, 2020. 18: p. 1221-1227.
2.Bluemel, C., et al., Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen. Cancer Immunology, Immunotherapy, 2010. 59(8): p. 1197-1209.
3.Wang, W., et al., NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy. Frontiers in Immunology, 2015. 6.
4.Croasdale, R., et al., Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition. Archives of Biochemistry and Biophysics, 2012. 526(2): p. 206-218.
5.Reusch, U., et al., A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. mAbs, 2014. 6(3): p. 727-738.