科普文章
FcγRIIB交联依赖性激动性抗体LVGN6051(抗CD137)和LVGN7409(抗CD40)的开发机制[1]
图1.TNFSF3-TNFRSF3复合体的聚集过程[1]。
三聚体膜结合TNFSF通过TNF同源区(TDH)结合到TNFRSF富含半胱氨酸区(CDR),招募三个TNFRSF受体分子,形成TNFSF3-TNFRSF3复合体。然而,对于大部分TNFRSF成员来说,仅依靠这种三聚体本身并不足以激活下游的信号通路(包括CD40、CD137、OX40和GITR),需要进一步在TNFSF3-TNFRSF3三聚体的基础上形成多聚体才能完全激活TNFRSFs信号。
图2 xLinkAb工作模型:FcγRIIB在TNFSFR-IgG-FcγRIIB复合物聚集中的作用[1]。
表1. 用于癌症治疗的CD137激动行抗体的临床研究,单药或联合用药
表2. 用于癌症治疗的CD40激动性抗体的临床研究,单药或联合用药
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